This case study explores the potential to transform smart port operations with the use of 5G-augmented autonomous drone technology supported by the GSMA’s Open Gateway APIs. It addresses how ports can leverage private 5G networks and autonomous UAVs (uncrewed aerial vehicles) to enhance their operational capabilities, enabling real-time monitoring and improved decision-making in the increasingly complex port environment. Drawing on Unmanned Life’s deployments in European ports, including the Port of Tyne, the Port of Bristol, the Port of Antwerp and the Port of Barcelona, this case study evaluates the impact of these technologies on efficiency, safety and the economics of port operations.